IntensiveCareMoni

Trialofearly,goal-directedresuscitationforsepticshock.ICMIndexNumber:/06‘Hot’topicAuthors:MounceyPR,OsbornTM,PowerGSetal.Reference:NEnglJMed05;7:0–.Trialregistrationnumber:ISRCTN.?MassachusettsMedicalSociety.ICMABSTRACTObjective

Todeterminewhetherthe6-hourEGDTresuscitationprotocolissuperior,intermsofclinicalandcosteffectivenessmeasures,tousualcareinpatientswithearlysepticshock.

Introduction

Thereisahighdeathrateinpatientswithseveresepsisandsepticshock.Guidelinesforresuscitationarelargelybasedonasingle-centrestudywhichfoundthatprotocolizeddeliveryof6hoursofearly,goal-directedtherapy(EGDT)topatientspresentingwithearlysepticshockreducedhospitalmortalityandhospitalstay.However,adoptionofEGDTforsepsishasbeenlimited,becauseofconcernsabouttheexternalvalidityofresultsfromonecentre,the







































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